Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart

Hematologic malignancies are frequently associated with cardiac pathologies. Mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a subset of acute myeloid leukemia patients, causing metabolic and epigenetic derangements. We have now discovered that altered metabolism in leukemic cells ha...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Karlstaedt, Anja, Zhang, Xiaotian, Vitrac, Heidi, Harmancey, Romain, Vasquez, Hernan, Wang, Jing Han, Goodell, Margaret A., Taegtmeyer, Heinrich
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027422/
https://ncbi.nlm.nih.gov/pubmed/27582470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601650113
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