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p38 Mitogen-Activated Protein Kinase-γ Inhibition by Long-Acting β(2) Adrenergic Agonists Reversed Steroid Insensitivity in Severe Asthma

Corticosteroid insensitivity (CI) is a major barrier to treating severe asthma. Despite intensive research, the molecular mechanism of CI remains uncertain. The aim of this study was to determine abnormality in corticosteroid action in severe asthma and to identify the molecular mechanism of the lon...

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Bibliografische gegevens
Hoofdauteurs: Mercado, Nicholas, To, Yasuo, Kobayashi, Yoshiki, Adcock, Ian M., Barnes, Peter J., Ito, Kazuhiro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228526/
https://ncbi.nlm.nih.gov/pubmed/21917909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.071993
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