Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

Rationale: Patients with chronic obstructive pulmonary disease (COPD) show a poor response to corticosteroids. This has been linked to a reduction of histone deacetylase-2 as a result of oxidative stress and is reversed by theophylline. Objectives: To determine the role of phosphoinositide-3-kinase-...

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Hlavní autoři: To, Yasuo, Ito, Kazuhiro, Kizawa, Yasuo, Failla, Marco, Ito, Misako, Kusama, Tadashi, Elliott, W. Mark, Hogg, James C., Adcock, Ian M., Barnes, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2010
Témata:
B. Chronic Obstructive Pulmonary Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2970861/
https://ncbi.nlm.nih.gov/pubmed/20224070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200906-0937OC
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