Repeated lipopolysaccharide exposure causes corticosteroid insensitive airway inflammation via activation of phosphoinositide-3-kinase δ pathway

Corticosteroid resistance is one of major barriers to effective management of chronic inflammatory respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and severe asthma. These patients often experience exacerbations with viral and/or bacterial infection, which may cause contin...

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Veröffentlicht in:Biochem Biophys Rep
Hauptverfasser: Ueda, Keitaro, Nishimoto, Yuki, Kimura, Genki, Masuko, Takashi, Barnes, Peter J., Ito, Kazuhiro, Kizawa, Yasuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5613638/
https://ncbi.nlm.nih.gov/pubmed/28955927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2016.07.020
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