Repeated lipopolysaccharide exposure causes corticosteroid insensitive airway inflammation via activation of phosphoinositide-3-kinase δ pathway

Corticosteroid resistance is one of major barriers to effective management of chronic inflammatory respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and severe asthma. These patients often experience exacerbations with viral and/or bacterial infection, which may cause contin...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Rep
Main Authors: Ueda, Keitaro, Nishimoto, Yuki, Kimura, Genki, Masuko, Takashi, Barnes, Peter J., Ito, Kazuhiro, Kizawa, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5613638/
https://ncbi.nlm.nih.gov/pubmed/28955927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2016.07.020
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