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Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation

Somatic hypermutation (SHM) and class-switch recombination (CSR) of the Ig gene require both the transcription of the locus and the expression of activation-induced cytidine deaminase (AID). During CSR, AID decreases the amount of topoisomerase I (Top1); this decrease alters the DNA structure and in...

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Bibliografski detalji
Glavni autori: Kobayashi, Maki, Sabouri, Zahra, Sabouri, Somayeh, Kitawaki, Yoko, Pommier, Yves, Abe, Takaya, Kiyonari, Hiroshi, Honjo, Tasuku
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228476/
https://ncbi.nlm.nih.gov/pubmed/22080610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114522108
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