लोड हो रहा है...

Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation

Somatic hypermutation (SHM) and class-switch recombination (CSR) of the Ig gene require both the transcription of the locus and the expression of activation-induced cytidine deaminase (AID). During CSR, AID decreases the amount of topoisomerase I (Top1); this decrease alters the DNA structure and in...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Kobayashi, Maki, Sabouri, Zahra, Sabouri, Somayeh, Kitawaki, Yoko, Pommier, Yves, Abe, Takaya, Kiyonari, Hiroshi, Honjo, Tasuku
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228476/
https://ncbi.nlm.nih.gov/pubmed/22080610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114522108
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!