Conformational lability in the class II MHC 3(10) helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange

HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA-DR1 by substitution of αF54, resulting in a protein with increased HLA-DM binding affinity, weakened MHC-peptide hydrogen bo...

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Main Authors: Painter, Corrie A., Negroni, Maria P., Kellersberger, Katherine A., Zavala-Ruiz, Zarixia, Evans, James E., Stern, Lawrence J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228433/
https://ncbi.nlm.nih.gov/pubmed/22084083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108074108
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