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Conformational lability in the class II MHC 3(10) helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange
HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA-DR1 by substitution of αF54, resulting in a protein with increased HLA-DM binding affinity, weakened MHC-peptide hydrogen bo...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3228433/ https://ncbi.nlm.nih.gov/pubmed/22084083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108074108 |
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