Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons

Neuronal migration is essential for the development of the mammalian brain. Here, we document severe defects in neuronal migration and reduced numbers of neurons in lamin B1–deficient mice. Lamin B1 deficiency resulted in striking abnormalities in the nuclear shape of cortical neurons; many neurons...

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Hauptverfasser: Coffinier, Catherine, Jung, Hea-Jin, Nobumori, Chika, Chang, Sandy, Tu, Yiping, Barnes, Richard H., Yoshinaga, Yuko, de Jong, Pieter J., Vergnes, Laurent, Reue, Karen, Fong, Loren G., Young, Stephen G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226484/
https://ncbi.nlm.nih.gov/pubmed/21976703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-06-0504
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