Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design

The DVD-Ig™ protein is a dual-specific immunoglobulin. Each of the two arms of the molecule contains two variable domains, an inner variable domain and an outer variable domain linked in tandem, each with binding specificity for different targets or epitopes. One area of on-going research involves d...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: DiGiammarino, Enrico L, Harlan, John E, Walter, Karl A, Ladror, Uri S, Edalji, Rohinton P, Hutchins, Charles W, Lake, Marc R, Greischar, Amy J, Liu, Junjian, Ghayur, Tariq, Jakob, Clarissa G
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2011
Témata:
Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225853/
https://ncbi.nlm.nih.gov/pubmed/21814039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.5.16326
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky