Identification of Anti-EGFR and Anti-ErbB3 Dual Variable Domains Immunoglobulin (DVD-Ig) Proteins with Unique Activities

Epidermal growth factor receptor (EGFR) and receptor tyrosine-protein kinase 3 (ErbB3) are two well-established targets in cancer therapy. There is significant crosstalk among these two receptors and others. To block signaling from both EGFR and ErbB3, we generated anti-EGFR and anti-ErbB3 DVD-Ig pr...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Gu, Jinming, Yang, Jinsong, Chang, Qing, Liu, Zhihong, Ghayur, Tariq, Gu, Jijie
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440733/
https://ncbi.nlm.nih.gov/pubmed/25997020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124135
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