Identification of Anti-ErbB2 Dual Variable Domain Immunoglobulin (DVD-Ig™) Proteins with Unique Activities

Inhibiting ErbB2 signaling with monoclonal antibodies (mAbs) or small molecules is an established therapeutic strategy in oncology. We have developed anti-ErbB2 Dual Variable Domain Immunoglobulin (DVD-Ig) proteins that capture the function of a combination of two anti-ErbB2 antibodies. In addition,...

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Detalhes bibliográficos
Main Authors: Gu, Jinming, Yang, Jinsong, Chang, Qing, Lu, Xiaoqing, Wang, Jieyi, Chen, Mingjiu, Ghayur, Tariq, Gu, Jijie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019538/
https://ncbi.nlm.nih.gov/pubmed/24824849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097292
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