Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration

Exudative age-related macular degeneration (AMD) is the most common cause of moderate and severe vision loss in developed countries. Intraocular injections of vascular endothelial growth factor (VEGF or VEGF-A)-neutralizing proteins provide substantial benefit, but frequent, long-term injections are...

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Publicado no:MAbs
Main Authors: Ding, Kun, Eaton, Lucia, Bowley, Diana, Rieser, Matthew, Chang, Qing, Harris, Maria C., Clabbers, Anca, Dong, Feng, Shen, Jikui, Hackett, Sean F., Touw, Debra S., Bixby, Jacqueline, Zhong, Suju, Benatuil, Lorenzo, Bose, Sahana, Grinnell, Christine, Preston, Gregory M., Iyer, Ramesh, Sadhukhan, Ramkrishna, Marchie, Susan, Overmeyer, Gary, Ghayur, Tariq, van Riet, Deborah A., Tang, Shibo, Campochario, Peter A., Gu, Jijie
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297536/
https://ncbi.nlm.nih.gov/pubmed/27929753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1268305
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