Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

Por Argiriadi, Maria A, Goedken, Eric R, Banach, David, Borhani, David W, Burchat, Andrew, Dixon, Richard W, Marcotte, Doug, Overmeyer, Gary, Pivorunas, Valerie, Sadhukhan, Ramkrishna, Sousa, Silvino, Moore, Nigel St John, Tomlinson, Medha, Voss, Jeffrey, Wang, Lu, Wishart, Neil, Woller, Kevin, Talanian, Robert V
Publicado em 2012

Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of...

Por Ding, Kun, Eaton, Lucia, Bowley, Diana, Rieser, Matthew, Chang, Qing, Harris, Maria C., Clabbers, Anca, Dong, Feng, Shen, Jikui, Hackett, Sean F., Touw, Debra S., Bixby, Jacqueline, Zhong, Suju, Benatuil, Lorenzo, Bose, Sahana, Grinnell, Christine, Preston, Gregory M., Iyer, Ramesh, Sadhukhan, Ramkrishna, Marchie, Susan, Overmeyer, Gary, Ghayur, Tariq, van Riet, Deborah A., Tang, Shibo, Campochario, Peter A., Gu, Jijie
Publicado no MAbs (2016)