Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design

Por DiGiammarino, Enrico L, Harlan, John E, Walter, Karl A, Ladror, Uri S, Edalji, Rohinton P, Hutchins, Charles W, Lake, Marc R, Greischar, Amy J, Liu, Junjian, Ghayur, Tariq, Jakob, Clarissa G
Publicado em 2011

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-R(S)

Por Sun, Chaohong, Song, Danying, Davis-Taber, Rachel A., Barrett, Leo W., Scott, Victoria E., Richardson, Paul L., Pereda-Lopez, Ana, Uchic, Marie E., Solomon, Larry R., Lake, Marc R., Walter, Karl A., Hajduk, Philip J., Olejniczak, Edward T.
Publicado em 2007

Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure

Por Longenecker, Kenton L., Stamper, Geoffrey F., Hajduk, Philip J., Fry, Elizabeth H., Jakob, Clarissa G., Harlan, John E., Edalji, Rohinton, Bartley, Diane M., Walter, Karl A., Solomon, Larry R., Holzman, Thomas F., Gu, Yu Gui, Lerner, Claude G., Beutel, Bruce A., Stoll, Vincent S.
Publicado em 2005