Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design

The DVD-Ig™ protein is a dual-specific immunoglobulin. Each of the two arms of the molecule contains two variable domains, an inner variable domain and an outer variable domain linked in tandem, each with binding specificity for different targets or epitopes. One area of on-going research involves d...

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Detalhes bibliográficos
Main Authors: DiGiammarino, Enrico L, Harlan, John E, Walter, Karl A, Ladror, Uri S, Edalji, Rohinton P, Hutchins, Charles W, Lake, Marc R, Greischar, Amy J, Liu, Junjian, Ghayur, Tariq, Jakob, Clarissa G
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225853/
https://ncbi.nlm.nih.gov/pubmed/21814039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.5.16326
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