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The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen
A dual-specific, tetravalent immunoglobulin G-like molecule, termed dual variable domain immunoglobulin (DVD-Ig™), is engineered to block two targets. Flexibility modulates Fc receptor and complement binding, but could result in undesirable cross-linking of surface antigens and downstream signaling....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4169030/ https://ncbi.nlm.nih.gov/pubmed/23572180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24258 |
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