The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen

A dual-specific, tetravalent immunoglobulin G-like molecule, termed dual variable domain immunoglobulin (DVD-Ig™), is engineered to block two targets. Flexibility modulates Fc receptor and complement binding, but could result in undesirable cross-linking of surface antigens and downstream signaling....

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Main Authors: Correia, Ivan, Sung, Joyce, Burton, Randall, Jakob, Clarissa G., Carragher, Bridget, Ghayur, Tariq, Radziejewski, Czeslaw
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169030/
https://ncbi.nlm.nih.gov/pubmed/23572180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24258
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