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Drug discovery targeting human 5-HT(2C) receptors: Residues S3.36 and Y7.43 impact ligand—binding pocket structure via hydrogen bond formation
Specific activation of serotonin (5-HT) 5-HT(2C) G protein-coupled receptors may be therapeutic for obesity and neuropsychiatric disorders. Mutagenesis coupled with computational and molecular modeling experiments based on the human β(2) adrenergic receptor structure were employed to delineate the i...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3224194/ https://ncbi.nlm.nih.gov/pubmed/22020288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2011.10.006 |
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