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Aromatic interactions impact ligand binding and function at serotonin 5-HT(2C) G protein-coupled receptors: Receptor homology modeling, ligand docking, and molecular dynamics results validated by experimental studies
The serotonin (5-hydroxytryptamine, 5-HT) 5-HT(2) G protein-coupled receptor (GPCR) family consists of types 2A, 2B, and 2C that share ~75% transmembrane (TM) sequence identity. Agonists for 5-HT(2C) receptors are under development for psychoses, whereas, at 5-HT(2A) receptors, antipsychotic effects...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3979624/ https://ncbi.nlm.nih.gov/pubmed/24729635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00268976.2013.833656 |
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