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Aromatic interactions impact ligand binding and function at serotonin 5-HT(2C) G protein-coupled receptors: Receptor homology modeling, ligand docking, and molecular dynamics results validated by experimental studies

The serotonin (5-hydroxytryptamine, 5-HT) 5-HT(2) G protein-coupled receptor (GPCR) family consists of types 2A, 2B, and 2C that share ~75% transmembrane (TM) sequence identity. Agonists for 5-HT(2C) receptors are under development for psychoses, whereas, at 5-HT(2A) receptors, antipsychotic effects...

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Podrobná bibliografie
Hlavní autoři: CÓRDOVA-SINTJAGO, TANIA, VILLA, NANCY, FANG, LIJUAN, BOOTH, RAYMOND G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979624/
https://ncbi.nlm.nih.gov/pubmed/24729635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00268976.2013.833656
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