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CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist

[Image: see text] We have identified several ligands with high binding affinities to the dopamine D3 receptor and excellent selectivity over the D2 and D1 receptors. CJ-1639 (17) binds to the D3 receptor with a K(i) value of 0.50 nM and displays a selectivity of >5000 times over D2 and D1 recepto...

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Autores principales: Chen, Jianyong, Collins, Gregory T., Levant, Beth, Woods, James, Deschamps, Jeffrey R., Wang, Shaomeng
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2011
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224040/
https://ncbi.nlm.nih.gov/pubmed/22125662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200100t
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