Oxy-Intermediates of Homoprotocatechuate 2,3-Dioxygenase: Facile Electron Transfer Between Substrates

Substrates homoprotocatechuate (HPCA) and O(2) bind to the Fe(II) of Homoprotocatechuate 2,3-dioxygenase (FeHPCD) in adjacent coordination sites. Transfer of an electron(s) from HPCA to O(2) via the iron is proposed to activate the substrates for reaction with each other to initiate aromatic ring cl...

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Bibliographic Details
Main Authors: Mbughuni, Michael M., Chakrabarti, Mrinmoy, Hayden, Joshua A., Meier, Katlyn K., Dalluge, Joseph J., Hendrich, Michael P., Münck, Eckard, Lipscomb, John D.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222778/
https://ncbi.nlm.nih.gov/pubmed/22011290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201436n
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