Substrate-Mediated Oxygen Activation by Homoprotocatechuate 2,3-Dioxygenase: Intermediates Formed by a Tyrosine 257 Variant

Homoprotocatechuate (HPCA; 3,4-dihydroxyphenylacetate or 4-carboxymethyl catechol) and O(2) bind in adjacent ligand sites of the active site Fe(II) of Homoprotocatechuate 2,3-Dioxygenase (FeHPCD). We have proposed that electron transfer from the chelated aromatic substrate through the Fe(II) to O(2)...

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Hlavní autoři: Mbughuni, Michael M., Meier, Katlyn K., Münck, Eckard, Lipscomb, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513391/
https://ncbi.nlm.nih.gov/pubmed/23066705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301114x
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