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NO Binding to Mn-Substituted Homoprotocatechuate 2,3-Dioxygenase: Relationship to O(2) Reactivity

Homoprotocatechuate 2,3-dioxygenase (FeHPCD) activates O(2) to catalyze the aromatic ring opening of 3,4-dihydroxyphenylacetic acid (HPCA). The enzyme requires Fe(II) for catalysis, but Mn(II) can be substituted (MnHPCD) with essentially no change in the steady-state kinetic parameters. Near simulta...

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Detalhes bibliográficos
Main Authors: Hayden, Joshua A., Farquhar, Erik R., Que, Lawrence, Lipscomb, John D., Hendrich, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936460/
https://ncbi.nlm.nih.gov/pubmed/23824380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-013-1016-2
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