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A Hyperactive Cobalt-Substituted Extradiol-Cleaving Catechol Dioxygenase

Homoprotocatechuate (HPCA) 2,3-dioxygenase from Brevibacterium fuscum (Fe-HPCD) has an Fe(II) center in its active site that can be replaced with Mn(II) or Co(II). While Mn-HPCD exhibits steady state kinetic parameters comparable to those of Fe-HPCD, Co-HPCD behaves somewhat differently exhibiting a...

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Autors principals: Fielding, Andrew J., Kovaleva, Elena G., Farquhar, Erik R., Lipscomb, John D., Que, Lawrence
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192431/
https://ncbi.nlm.nih.gov/pubmed/21153851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-010-0732-0
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