Long-term Rescue of a Familial Hypertrophic Cardiomyopathy Caused by a Mutation in the Thin Filament Protein, Tropomyosin, via Modulation of a Calcium Cycling Protein

We have recently shown that a temporary increase in sarcoplasmic reticulum (SR) cycling via adenovirus-mediated overexpression of sarcoplasmic-endoplasmic reticulum ATPase (SERCA2) transiently improves relaxation and delays hypertrophic remodeling in a familial hypertrophic cardiomyopathy (FHC) caus...

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Autors principals: Gaffin, Robert D, Peña, James R, Alves, Marco S L, Dias, Fernando A L, Chowdhury, Shamim, Heinrich, Lynley S, Goldspink, Paul H, Kranias, Evangelia G, Wieczorek, David F, Wolska, Beata M
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221410/
https://ncbi.nlm.nih.gov/pubmed/21840315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.07.026
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