Facilitated Cross-Bridge Interactions with Thin Filaments by Familial Hypertrophic Cardiomyopathy Mutations in α-Tropomyosin

Familial hypertrophic cardiomyopathy (FHC) is a disease of cardiac sarcomeres. To identify molecular mechanisms underlying FHC pathology, functional and structural differences in three FHC-related mutations in recombinant α-Tm (V95A, D175N, and E180G) were characterized using both conventional and m...

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Detalhes bibliográficos
Main Authors: Wang, Fang, Brunet, Nicolas M., Grubich, Justin R., Bienkiewicz, Ewa A., Asbury, Thomas M., Compton, Lisa A., Mihajlović, Goran, Miller, Victor F., Chase, P. Bryant
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237018/
https://ncbi.nlm.nih.gov/pubmed/22187526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/435271
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