Micromechanical Thermal Assays of Ca(2+)-Regulated Thin-Filament Function and Modulation by Hypertrophic Cardiomyopathy Mutants of Human Cardiac Troponin

Microfabricated thermoelectric controllers can be employed to investigate mechanisms underlying myosin-driven sliding of Ca(2+)-regulated actin and disease-associated mutations in myofilament proteins. Specifically, we examined actin filament sliding—with or without human cardiac troponin (Tn) and α...

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Detalhes bibliográficos
Main Authors: Brunet, Nicolas M., Mihajlović, Goran, Aledealat, Khaled, Wang, Fang, Xiong, Peng, von Molnár, Stephan, Chase, P. Bryant
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303698/
https://ncbi.nlm.nih.gov/pubmed/22500102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/657523
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