Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

OBJECTIVE: The ATP-binding cassette transporter A1 (ABCA1) is essential for normal insulin secretion from β-cells. The aim of this study was to elucidate the mechanisms underlying the impaired insulin secretion in islets lacking β-cell ABCA1. RESEARCH DESIGN AND METHODS: Calcium imaging, patch clamp...

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Detalhes bibliográficos
Main Authors: Kruit, Janine K., Wijesekara, Nadeeja, Fox, Jocelyn E. Manning, Dai, Xiao-Qing, Brunham, Liam R., Searle, Gavin J., Morgan, Garry P., Costin, Adam J., Tang, Renmei, Bhattacharjee, Alpana, Johnson, James D., Light, Peter E., Marsh, Brad J., MacDonald, Patrick E., Verchere, C. Bruce, Hayden, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219942/
https://ncbi.nlm.nih.gov/pubmed/21998401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0081
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