Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

OBJECTIVE: The ATP-binding cassette transporter A1 (ABCA1) is essential for normal insulin secretion from β-cells. The aim of this study was to elucidate the mechanisms underlying the impaired insulin secretion in islets lacking β-cell ABCA1. RESEARCH DESIGN AND METHODS: Calcium imaging, patch clamp...

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Main Authors: Kruit, Janine K., Wijesekara, Nadeeja, Fox, Jocelyn E. Manning, Dai, Xiao-Qing, Brunham, Liam R., Searle, Gavin J., Morgan, Garry P., Costin, Adam J., Tang, Renmei, Bhattacharjee, Alpana, Johnson, James D., Light, Peter E., Marsh, Brad J., MacDonald, Patrick E., Verchere, C. Bruce, Hayden, Michael R.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2011
Teme:
Islet Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219942/
https://ncbi.nlm.nih.gov/pubmed/21998401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0081
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