Somatic structural rearrangements in genetically engineered mouse mammary tumors

BACKGROUND: Here we present the first paired-end sequencing of tumors from genetically engineered mouse models of cancer to determine how faithfully these models recapitulate the landscape of somatic rearrangements found in human tumors. These were models of Trp53-mutated breast cancer, Brca1- and B...

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Detalhes bibliográficos
Main Authors: Varela, Ignacio, Klijn, Christiaan, Stephens, Phillip J, Mudie, Laura J, Stebbings, Lucy, Galappaththige, Danushka, van der Gulden, Hanneke, Schut, Eva, Klarenbeek, Sjoerd, Campbell, Peter J, Wessels, Lodewyk FA, Stratton, Michael R, Jonkers, Jos, Futreal, P Andrew, Adams, David J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218656/
https://ncbi.nlm.nih.gov/pubmed/20942901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2010-11-10-r100
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