Involvement of Akt and mTOR in chemotherapeutic and hormonal-based drug resistance and response to radiation in breast cancer cells

Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs and radiation is clearly important as these are common treatment approaches. Signaling cascades often involved in chemo-, hormonal- and radiation resistance are the Ras/PI3K/PTE N/Akt/mTO R, Ras/Raf/MEK/ERK...

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Main Authors: Steelman, Linda S, Navolanic, Patrick, Chappell, William H, Abrams, Stephen L, Wong, Ellis WT, Martelli, Alberto M, Cocco, Lucio, Stivala, Franca, Libra, Massimo, Nicoletti, Ferdinando, Drobot, Lyudmyla B, Franklin, Richard A, McCubrey, James A
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218601/
https://ncbi.nlm.nih.gov/pubmed/21869603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.17.17119
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