Replacement of C-Terminal Histidines Uncouples Membrane Insertion and Translocation in Diphtheria Toxin T-Domain

The translocation (T) domain plays a key role in the action of diphtheria toxin and is responsible for transferring the N-terminus-attached catalytic domain across the endosomal membrane into the cytosol in response to acidification. The T-domain undergoes a series of pH-triggered conformational cha...

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Autors principals: Rodnin, Mykola V., Kyrychenko, Alexander, Kienker, Paul, Sharma, Onkar, Vargas-Uribe, Mauricio, Collier, R. John, Finkelstein, Alan, Ladokhin, Alexey S.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2011
Matèries:
Biophysical Letter
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218347/
https://ncbi.nlm.nih.gov/pubmed/22098755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.10.018
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