CONFORMATIONAL SWITCHING OF THE DIPHTHERIA TOXIN T-DOMAIN

The diphtheria toxin T-domain translocates the catalytic C-domain across the endosomal membrane in response to acidification. To elucidate the role of histidine protonation in modulating pH-dependent membrane action of the T-domain, we have used site-directed mutagenesis coupled with spectroscopic a...

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Main Authors: Rodnin, Mykola V., Kyrychenko, Alexander, Kienker, Paul, Sharma, Onkar, Posokhov, Yevgen O., Collier, R. John, Finkelstein, Alan, Ladokhin, Alexey S.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042302/
https://ncbi.nlm.nih.gov/pubmed/20654627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.07.024
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