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CONFORMATIONAL SWITCHING OF THE DIPHTHERIA TOXIN T-DOMAIN
The diphtheria toxin T-domain translocates the catalytic C-domain across the endosomal membrane in response to acidification. To elucidate the role of histidine protonation in modulating pH-dependent membrane action of the T-domain, we have used site-directed mutagenesis coupled with spectroscopic a...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3042302/ https://ncbi.nlm.nih.gov/pubmed/20654627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.07.024 |
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