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Crucial Role of H322 in the Folding of Diphtheria Toxin T-Domain into the Open-Channel State

The translocation (T) domain plays a key role in the entry of diphtheria toxin into the cell. Upon endosomal acidification, the T-domain undergoes a series of conformational changes that lead to its membrane insertion and formation of a channel. Recently, we have reported that the triple replacement...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Vargas-Uribe, Mauricio, Rodnin, Mykola V., Kienker, Paul, Finkelstein, Alan, Ladokhin, Alexey S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772984/
https://ncbi.nlm.nih.gov/pubmed/23621842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400249f
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