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Cellular Entry of the Diphtheria Toxin Does Not Require the Formation of the Open-Channel State by Its Translocation Domain

Cellular entry of diphtheria toxin is a multistage process involving receptor targeting, endocytosis, and translocation of the catalytic domain across the endosomal membrane into the cytosol. The latter is ensured by the translocation (T) domain of the toxin, capable of undergoing conformational ref...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxins (Basel)
Prif Awduron: Ladokhin, Alexey S., Vargas-Uribe, Mauricio, Rodnin, Mykola V., Ghatak, Chiranjib, Sharma, Onkar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666346/
https://ncbi.nlm.nih.gov/pubmed/28937631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins9100299
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