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Cellular Entry of the Diphtheria Toxin Does Not Require the Formation of the Open-Channel State by Its Translocation Domain

Cellular entry of diphtheria toxin is a multistage process involving receptor targeting, endocytosis, and translocation of the catalytic domain across the endosomal membrane into the cytosol. The latter is ensured by the translocation (T) domain of the toxin, capable of undergoing conformational ref...

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Vydáno v:Toxins (Basel)
Hlavní autoři: Ladokhin, Alexey S., Vargas-Uribe, Mauricio, Rodnin, Mykola V., Ghatak, Chiranjib, Sharma, Onkar
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666346/
https://ncbi.nlm.nih.gov/pubmed/28937631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins9100299
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