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Cellular Entry of the Diphtheria Toxin Does Not Require the Formation of the Open-Channel State by Its Translocation Domain

Cellular entry of diphtheria toxin is a multistage process involving receptor targeting, endocytosis, and translocation of the catalytic domain across the endosomal membrane into the cytosol. The latter is ensured by the translocation (T) domain of the toxin, capable of undergoing conformational ref...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Ladokhin, Alexey S., Vargas-Uribe, Mauricio, Rodnin, Mykola V., Ghatak, Chiranjib, Sharma, Onkar
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666346/
https://ncbi.nlm.nih.gov/pubmed/28937631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins9100299
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