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Crucial Role of H322 in the Folding of Diphtheria Toxin T-Domain into the Open-Channel State
The translocation (T) domain plays a key role in the entry of diphtheria toxin into the cell. Upon endosomal acidification, the T-domain undergoes a series of conformational changes that lead to its membrane insertion and formation of a channel. Recently, we have reported that the triple replacement...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3772984/ https://ncbi.nlm.nih.gov/pubmed/23621842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400249f |
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