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PH-TRIGGERED CONFORMATIONAL SWITCHING OF THE DIPHTHERIA TOXIN T-DOMAIN: THE ROLES OF N-TERMINAL HISTIDINES
pH-Induced conformational switching is essential for functioning of diphtheria toxin, which undergoes a membrane insertion/translocation transition triggered by endosomal acidification as a key step of cellular entry. In order to establish the sequence of molecular rearrangements and side chain prot...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3782538/ https://ncbi.nlm.nih.gov/pubmed/23648837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.04.030 |
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