PH-TRIGGERED CONFORMATIONAL SWITCHING OF THE DIPHTHERIA TOXIN T-DOMAIN: THE ROLES OF N-TERMINAL HISTIDINES

pH-Induced conformational switching is essential for functioning of diphtheria toxin, which undergoes a membrane insertion/translocation transition triggered by endosomal acidification as a key step of cellular entry. In order to establish the sequence of molecular rearrangements and side chain prot...

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Detalhes bibliográficos
Main Authors: Kurnikov, Igor V., Kyrychenko, Alexander, Flores-Canales, Jose Christian, Rodnin, Mykola V., Simakov, Nikolay, Vargas-Uribe, Mauricio, Posokhov, Yevgen O., Kurnikova, Maria, Ladokhin, Alexey S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782538/
https://ncbi.nlm.nih.gov/pubmed/23648837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.04.030
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