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Shear stress–induced unfolding of VWF accelerates oxidation of key methionine residues in the A1A2A3 region
VWF is required for platelet adhesion to sites of vessel injury, a process vital for both hemostasis and thrombosis. Enhanced VWF secretion and oxidative stress are both hallmarks of inflammation. We recently showed that the neutrophil oxidant hypochlorous acid (HOCl) inhibits VWF proteolysis by ADA...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3217410/ https://ncbi.nlm.nih.gov/pubmed/21917758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-331074 |
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