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Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress
Endothelial cells secrete prothrombotic ultralarge von Willebrand factor (VWF) multimers, and the metalloprotease ADAMTS13 cleaves them into smaller, less dangerous multimers. This reaction is stimulated by tensile force applied to the VWF substrate, which may occur on cell surfaces or in the circul...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2200832/ https://ncbi.nlm.nih.gov/pubmed/17901248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-093021 |
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