Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13

The function of thrombospondin-1 (TSP-1) in hemostasis was investigated in wild-type (WT) and Tsp1(-/-) mice, via dynamic platelet interaction studies with A23187-stimulated mesenteric endothelium and with photochemically injured cecum subendothelium. Injected calcein-labeled WT platelets tethered o...

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Detalhes bibliográficos
Main Authors: Bonnefoy, Arnaud, Daenens, Kim, Feys, Hendrik B., De Vos, Rita, Vandervoort, Petra, Vermylen, Jos, Lawler, Jack, Hoylaerts, Marc F.
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895898/
https://ncbi.nlm.nih.gov/pubmed/16204318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-12-4856
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