Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress

Endothelial cells secrete prothrombotic ultralarge von Willebrand factor (VWF) multimers, and the metalloprotease ADAMTS13 cleaves them into smaller, less dangerous multimers. This reaction is stimulated by tensile force applied to the VWF substrate, which may occur on cell surfaces or in the circul...

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Bibliographic Details
Main Authors: Shim, Kyuhwan, Anderson, Patricia J., Tuley, Elodee A., Wiswall, Erin, Evan Sadler, J.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Hemostasis, Thrombosis, and Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200832/
https://ncbi.nlm.nih.gov/pubmed/17901248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-093021
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