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von Willebrand factor self-association is regulated by the shear-dependent unfolding of the A2 domain
von Willebrand factor (VWF) self-association results in the homotypic binding of VWF upon exposure to fluid shear. The molecular mechanism of this process is not established. In this study, we demonstrate that the shear-dependent unfolding of the VWF A2 domain in the multimeric protein is a major re...
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| Publicado en: | Blood Adv |
|---|---|
| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6457215/ https://ncbi.nlm.nih.gov/pubmed/30936056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018030122 |
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