Platelet GpIbα Binding to von Willebrand Factor Under Fluid Shear: Contributions of the D'D3‐Domain, A1‐Domain Flanking Peptide and O‐Linked Glycans

BACKGROUND: Von Willebrand Factor (VWF) A1‐domain binding to platelet receptor GpIbα is an important fluid‐shear dependent interaction that regulates both soluble VWF binding to platelets, and platelet tethering onto immobilized VWF. We evaluated the roles of different structural elements at the N‐t...

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Bibliographic Details
Published in:J Am Heart Assoc
Main Authors: Madabhushi, Sri R., Zhang, Changjie, Kelkar, Anju, Dayananda, Kannayakanahalli M., Neelamegham, Sriram
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2014
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323794/
https://ncbi.nlm.nih.gov/pubmed/25341886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001420
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