Platelet GpIbα Binding to von Willebrand Factor Under Fluid Shear: Contributions of the D'D3‐Domain, A1‐Domain Flanking Peptide and O‐Linked Glycans

BACKGROUND: Von Willebrand Factor (VWF) A1‐domain binding to platelet receptor GpIbα is an important fluid‐shear dependent interaction that regulates both soluble VWF binding to platelets, and platelet tethering onto immobilized VWF. We evaluated the roles of different structural elements at the N‐t...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Am Heart Assoc
Main Authors: Madabhushi, Sri R., Zhang, Changjie, Kelkar, Anju, Dayananda, Kannayakanahalli M., Neelamegham, Sriram
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2014
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323794/
https://ncbi.nlm.nih.gov/pubmed/25341886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001420
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