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Platelet GpIbα Binding to von Willebrand Factor Under Fluid Shear: Contributions of the D'D3‐Domain, A1‐Domain Flanking Peptide and O‐Linked Glycans

BACKGROUND: Von Willebrand Factor (VWF) A1‐domain binding to platelet receptor GpIbα is an important fluid‐shear dependent interaction that regulates both soluble VWF binding to platelets, and platelet tethering onto immobilized VWF. We evaluated the roles of different structural elements at the N‐t...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Madabhushi, Sri R., Zhang, Changjie, Kelkar, Anju, Dayananda, Kannayakanahalli M., Neelamegham, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323794/
https://ncbi.nlm.nih.gov/pubmed/25341886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001420
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