Platelet GpIbα Binding to von Willebrand Factor Under Fluid Shear: Contributions of the D'D3‐Domain, A1‐Domain Flanking Peptide and O‐Linked Glycans

BACKGROUND: Von Willebrand Factor (VWF) A1‐domain binding to platelet receptor GpIbα is an important fluid‐shear dependent interaction that regulates both soluble VWF binding to platelets, and platelet tethering onto immobilized VWF. We evaluated the roles of different structural elements at the N‐t...

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Detaylı Bibliyografya
Yayımlandı:J Am Heart Assoc
Asıl Yazarlar: Madabhushi, Sri R., Zhang, Changjie, Kelkar, Anju, Dayananda, Kannayakanahalli M., Neelamegham, Sriram
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Publishing Ltd 2014
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323794/
https://ncbi.nlm.nih.gov/pubmed/25341886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.114.001420
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