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E. coli derived Von Willebrand Factor-A2 domain FRET proteins that quantify ADAMTS13 activity

The cleavage of the A2-domain of Von Willebrand Factor (VWF) by the metalloprotease ADAMTS13 regulates VWF size and platelet thrombosis rates. Reduction or inhibition of this enzyme activity leads to thrombotic thrombocytopenic purpura (TTP). We generated a set of novel molecules called VWF-A2 FRET...

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Hlavní autoři: Dayananda, Kannayakanahalli M., Gogia, Shobhit, Neelamegham, Sriram
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031717/
https://ncbi.nlm.nih.gov/pubmed/21146487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2010.12.005
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