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E. coli derived Von Willebrand Factor-A2 domain FRET proteins that quantify ADAMTS13 activity
The cleavage of the A2-domain of Von Willebrand Factor (VWF) by the metalloprotease ADAMTS13 regulates VWF size and platelet thrombosis rates. Reduction or inhibition of this enzyme activity leads to thrombotic thrombocytopenic purpura (TTP). We generated a set of novel molecules called VWF-A2 FRET...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031717/ https://ncbi.nlm.nih.gov/pubmed/21146487 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2010.12.005 |
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