VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease

During posttranslational modifications of von Willebrand factor (VWF), the VWF propeptide (VWFpp) is cleaved. The ratio between VWFpp and VWF antigen (VWF:Ag) and the ratio between factor VIII (FVIII:C) and VWF:Ag may be used to assess synthesis and clearance of VWF. We analyzed the contribution of...

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Main Authors: Eikenboom, Jeroen, Federici, Augusto B., Dirven, Richard J., Castaman, Giancarlo, Rodeghiero, Francesco, Budde, Ulrich, Schneppenheim, Reinhard, Batlle, Javier, Canciani, Maria Teresa, Goudemand, Jenny, Peake, Ian, Goodeve, Anne, Tosetto, Alberto, Meyer, Dominique, Fressinaud, Edith, Mazurier, Claudine, Ingerslev, Jørgen, Vorlova, Zdena, Habart, David, Holmberg, Lars, Lethagen, Stefan, Pasi, John, Hill, Frank
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2013
Fag:
Thrombosis and Hemostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191434/
https://ncbi.nlm.nih.gov/pubmed/23349392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-455089
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